The global Polyhydroxyalkanoate (PHA) market size is projected to reach USD 0.37 billion by 2029

• Global Polyhydroxyalkanoate (PHA) Market

Polyhydroxyalkanoate (PHA) is a storage material for carbon and energy sources in microorganisms. When carbon sources are abundant and other nutrients (N/P/S, etc.) are insufficient, they will be synthesized in different microorganisms. PHA synthesis the main costs are the substrate cost in the fermentation stage and the cost of downstream extraction and purification.

The diversity of PHA monomer structure is mainly different from the difference in the side chain group on the C-3 position, in which the monomer with 3-5 carbon atoms is short-chain PHA (SCL PHA), and the number of carbon atoms above 6 is medium and long chain. PHA (MCL PHA). In the general structural formula of PHA, R can be an alkenyl group, a benzene ring, an alkyl group, etc., usually m is 1, and n represents the degree of polymerization, which determines the molecular weight of the polymer. Poly-3-hydroxybutyric acid (PHB) with a methyl side chain is the most common. Poly-3-hydroxybutyric acid (PHB) has thermoplasticity like polypropylene and has brittleness and poor thermal stability; polyhydroxybutyric acid-co-hydroxyvaleric acid copolymer (PHBV) has more good strength, hardness, greater elasticity, lower melting point. Short-chain PHA presents a hard crystal; medium- and long-chain PHA is a thermoplastic elastomer with good flexibility, low hardness, slow crystallization rate, and the melting temperature is mostly kept in the range of 39-61 °C; short-chain medium- and long-chain copolymerization The PHA (SCL-MCL PHA), by adjusting the monomer ratio, obtains a copolymerized PHA material that combines the excellent properties of short-chain and medium-long chains. PHA synthesis methods include microbial fermentation (wild bacteria method, recombinant engineering bacteria method), transgenic plant method, activated sludge method, and microbial fermentation method are the main ways of biosynthesizing PHA at present. The microorganisms that synthesize PHA are mainly divided into three categories: pure bacteria, engineering bacteria and mixed bacteria. In the process of biosynthesizing PHA, there are disadvantages such as high sterilization cost, high consumption of fresh water, and easy contamination by discontinuous fermentation, resulting in lower competitiveness of industrial biotechnology compared with chemical processes.

There are two methods of synthesis of PHA: biosynthesis and chemical synthesis.

Biosynthesis:

①Bacterial synthesis method: Different microorganisms can convert different fermentation substrates into PHA under suitable conditions.

② Genetic engineering method: introduce the relevant enzymes of Alcaligenes eutrophic bacteria that synthesize PHB into oil plants to obtain transgenic plants, and clone and synthesize PHB from the cells or plastids of these transgenic plants. The genetic method saves the separation and purification steps of PHB and bacteria in the bacterial method, which can reduce the synthesis cost, but the low yield and the difficulty of purification seriously restrict the large-scale production and application of PHA.

③Activated sludge method: Activated sludge is a bacterial mass containing a large number of active microorganisms and a small number of impurities and contains a large amount of biologically active substances and organic substances. The specific process is taking the remaining activated sludge from the sewage plant and put it into the SBR reactor. After the sludge is in good condition, the color changes from brown to light yellow, and the activity is stable, it enters the next cycle of domestication process, and finally discharges a batch of the activated sludge rich in PHA can be extracted by PHA, and then a new batch of excess sludge can be added again and repeat steps 1 to 3 to obtain high-yield PHA sludge in batches.

Chemical synthesis method:

①the bond between the carbonyl group in the lactone ring and the oxygen atom is broken, and there are few racemates in the product.

②the bond between the β-carbon atom and the oxygen atom in the lactone ring is broken, and the enantiomer can be racemized.

According to the number of carbon atoms in the PHA monomer, PHA can be divided into two categories:

1. According to the number of carbon atoms in the PHA monomer, PHA can be divided into two categories

①Short chain: the number of carbon atoms is 3-5, such as PHB, PHV.

②Medium and long chain: the number of carbon atoms is 6-14, such as PHHx, PHO

2. According to the different types of monomers, PHA can be divided into two categories

①Homopolymer, the number of monomers is 1, such as PHB, PHV.

②Copolymer, the number of monomers is greater than or equal to 2, such as PHBHHx, PHBV

At present, the main ones commercialized on the market are PHB, PHBV, P34HB, and PHBHHx.

According to the new market research report “Global Polyhydroxyalkanoate (PHA) Market Report 2023-2029”, published by GIResearch, the global Polyhydroxyalkanoate (PHA) market size is projected to reach USD 0.37 billion by 2029, at a CAGR of 10.3% during the forecast period.

• Global Polyhydroxyalkanoate (PHA) MarketSize(US$ Million), 2018-2029

Source: GlobalInfoResearch, “Global Polyhydroxyalkanoate (PHA) Market 2024 by Manufacturers, Regions, Type and Application, Forecast to 2030”(PHA) Market Report 2023-2029 (published in 2023). If you need the latest data, plaese contact GIResearch..

• Global Polyhydroxyalkanoate (PHA) Top11Players Ranking and Market Share (Ranking is based on the revenue of 2022, continually updated)

Source: GlobalInfoResearch, “Global Polyhydroxyalkanoate (PHA) Market 2024 by Manufacturers, Regions, Type and Application, Forecast to 2030”(PHA) Market Report 2023-2029 (published in 2023). If you need the latest data, plaese contact GIResearch.

The global key manufacturers of Polyhydroxyalkanoate (PHA) include Danimer Scientific, Kaneka, Nafigate Corporation, Tian'an Biopolymer, Biomer, Shenzhen Ecomann Technology, RWDC Industries, Newlight Technologies, CJ CheilJedang, PHB Industrial S.A., etc. In 2022, the global top five players had a share approximately 89.0% in terms of revenue.

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